CATECHOL N-METHYLHYDRAZIDE CARBAMIC ESTER DERIVATIVE AND PREPARATION METHOD THEREOF

摘要

PURPOSE: A novel catechol N-methylhydrazide carbamic ester derivative, its preparation method and a pharmaceutical composition containing the derivative are provided, which derivative has the inhibition effect on phosphodiesterase (PDE) IV or a tumor necrosis factor (TNF). CONSTITUTION: The catechol N-methylhydrazide carbamic ester derivative is represented by the formula 1, wherein R1 is a cycloalkyl group of C3-C7, an indanyl group or a benzyl group; R2 is a methyl group; Y is -C(=O)O-; R3 is an alkyl group of C1-C6 substituted or unsubstituted with one or two halogen atom or compound of C1-C3 selectively; an cycloalkyl group of C1-C6 substituted or unsubstituted with one or two compound of C1-C3 selectively; a phenyl group substituted or unsubstituted with one or two nitro group, nitryl group, halogen atom, alkyl group of C1-C3 or alkoxy group of C1-C3 selectively; or a benzyl group substituted or unsubstituted with one or two nitro group, nitryl group, halogen atom selectively, and the halogen atom is Cl, F or Br.