| 摘要 |
PROBLEM TO BE SOLVED: To provide an eudistomin intermediate compound improved with the yield and stereospecific selectivity in the forming process of a 7-membered oxathiazepine skeleton, a method for producing the same intermediate, and a new eudistomin analog compound. SOLUTION: This eudistomin synthetic intermediate is expressed by the general formula (I) (wherein, R<1> to R<4> are each H, a lower alkyl or the like; R<5> is H; R<6> is H, silyl or the like; R<7> is H, a lower alkyl or the like), in which the absolute stereospecific configurations at 1 and 10th positions are (1S, 10R), (1R, 10S), (1S, 10S) or (1R, 10R). As a concrete example of the compound, a compound expressed by the formula II (wherein, Boc is a substituting group such as tertiary butoxycarbonyl, etc.), can be sited. |
