发明名称 |
Kombinert terapi mot tumorer innbefattende substituerte akryloyldistamycinderivater og alkyleringsmidler |
摘要 |
Compounds which are alpha-halogenoacryloyl distamycin derivatives of formula (I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies. |
申请公布号 |
NO20026077(A) |
申请公布日期 |
2002.12.18 |
申请号 |
NO20020006077 |
申请日期 |
2002.12.18 |
申请人 |
PHARMACIA ITALIA SPA |
发明人 |
GERONI, MARIA CRISTINA ROSA;COZZI, PAOLO;BERIA, ITALO |
分类号 |
C07D403/14;A61K31/282;A61K31/4025;A61K31/4155;A61K31/4178;A61K33/24;A61K45/00;A61K45/06;A61P35/00;A61P43/00;C07D207/34;(IPC1-7):A61K |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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