MARKER FOR FAMILY LINE DIAGNOSIS

摘要

PROBLEM TO BE SOLVED: To separate and identify a new gene relating to polyglutamine diseases and clarify the polypeptide coded by the gene and to provide an examination technique and a preventing and/or treating agent for polyglutamine diseases using the gene or polypeptide. SOLUTION: The invention relates to a new gene containing a polynucleotide composed of a base sequence described in the sequence No.1, No.3, No.5, No.7 or No.9 of a sequence table (refer to the specification) having a CAG repeat encoding a polyglutamine, a polypeptide coded by the gene, a means for the diagnosis of family line taking advantage of the polymorphism of each gene derived from the difference of the number of the CAG repeats, a probe composed of a partial sequence of the gene and usable for the family line diagnosis and a preventing and/or treating agent for polyglutamine diseases based on the inhibition of the expression of the gene and the function of a polypeptide coded by the gene.