Substituted phenyloxazolidinones and their use as antibiotics

摘要

The invention concerns compounds of formula (I),wherein, for example,R1 is of the formula -NHC(=O)Ra wherein Ra is (1-4C)alkyl;R2 and R3 are independently hydrogen or fluoro;R5 and R6 are, for example, hydrogen;R4 is -X-Y-Het.;wherein, for example,X is a direct bond and Y is -(CH2)m- or -CONH-(CH2)m-;or X is -(CH2)n- and Y is -S(O)p-(CH2)m-;or X is -CH2O-or -CH2NH- and Y is -CO-(CH2)m-;wherein n is 1, 2 or 3; m is 0, 1, 2 or 3 and p is 0, 1 or 2;wherein Het. is a heterocyclic ring, unsaturated or saturated, optionally substituted by, for example, (1-4C)alkyl, halo, cyano, nitro or amino; pharmaceutically acceptable salts and in vivo hydrolysable ester thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.