发明名称 |
Fungal efflux pump inhibitors |
摘要 |
The use of compounds of the milbemycin class as inhibitors of efflux pumps in microbes or other cells is described, along with pharmaceutical compositions incorporating a milbemycin. Also described is a method of screening for compounds which inhibit a CDR1, CDR2, BEN, or FLU1 efflux pump or a pump with components having a high level of protein level sequence similarity with the components of those efflux pumps.
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申请公布号 |
US6495591(B1) |
申请公布日期 |
2002.12.17 |
申请号 |
US19980164609 |
申请日期 |
1998.10.01 |
申请人 |
ESSENTIAL THERAPEUTICS, INC. |
发明人 |
CHAMBERLAND SUZANNE;LEE MAY;LOMOVSKAYA OLGA |
分类号 |
A61K31/00;A61K31/335;A61K31/365;A61K31/41;A61K31/495;A61K31/70;C12P19/62;(IPC1-7):A61K31/335 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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