5 ALKYLPYRIDO[2,3 D]PYRIMIDINES TYROSINE KINASE INHIBITORS.

摘要

Disclosed are compounds of the formula (I) wherein: R2 is hydrogen, alkyl, or cycloalkyl; R3 is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkynyl, lower alkenyl, nitrile, nitro, COR4, CO2R4, CONR4R5, CONR4OR5, SO2NR4R5, SO2NR4R5, SO2R4, SO3R4, formula (II), or NR4R5; Y is N or CR7; R9 is lower alkyl, haloalkyl, or aryl; X and Z are independently hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, nitrile, nitro, NR4R5, N(O)R4R5, NR4R5R6W, SR4, C(O)R4, CO2R4, CONR4R5, SO2NR4R5, SO2R4, SO3R4, P(O)(OR4)(OR5), T(CH2)mQR4, C(O)T(CH2)mQR4, or NR4C(O)T(CH2)mQR5; m is 1 to 6. These compounds are useful for treating cell proliferative disorders, such as cancer, atherosclerosis, and restenosis. These compounds are potent inhibitors of cyclin dependent kinases (cdks) and growth factor mediated kinases.