| 摘要 |
<p>A member of the tumor necrosis factor family and its receptor are described. This member is primarily expressed in B cells and its expression correlates to increases in the number of B cells and immunoglobulins produced. The natural, preferred human ortholog is here called AGP 3R. The protein is a type III transmembrane protein and has an amino terminal extracellular domain, a transmembrane domain, and a carboxy terminal intracellular domain. AGP 3R related proteins of the invention may be membrane associated or in soluble form, recombinantly produced or isolated after natural production. The invention provides for nucleic acids encoding such AGP 3R related proteins, vectors and host cells expressing the polypeptides, and methods for producing recombinant proteins. Antibodies or fragments thereof that specifically bind the proteins are also provided.</p> |
