SPHINGOSINE KINASE INTERACTS WITH TRAF2 AND MODULATES TUMOR NECROSIS FACTOR-INDUCED CELLULAR ACTIVITY
摘要
The present invention relates generally to a method of modulating cytokine-mediated cellular activity and to agents useful for same. More particularly, the present invention contemplates a method of modulating tumor necrosis factor-mediated cellular activity by modulating an intracellular sphingosine kinase-dependent signalling mechanism. The method of the present invention is useful, <i>inter alia</i>, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate cytokine-mediated cellular activity The present invention is further directed to methods for identifying and/or designing agents capable of modulating the subject sphingosine kinase-dependent signalling mechanism.
申请公布号
WO02098458(A1)
申请公布日期
2002.12.12
申请号
WO2002AU00710
申请日期
2002.06.03
申请人
MEDVET SCIENCE PTY LTD;XIA, PU;WANG, LIJUN;VADAS, MATHEW;GAMBLE, JENNIFER;MORETTI, PAUL;PITSON, STUART
发明人
XIA, PU;WANG, LIJUN;VADAS, MATHEW;GAMBLE, JENNIFER;MORETTI, PAUL;PITSON, STUART