PYRAZINO 1',2':1,6 PYRIDO 3,4-B INDOLE1,4-DIONE DERIVATIVES

摘要

Compounds of the general structural formula (I), and use of the compounds an d salts and solvates thereof, as thereapeutic agents. In particular, the invention relates to compounds that are potent and selective inhibitors of cyclic guanosine 3', 5'-monophosphate specific phosphodiesterase (cGMP- specific PDE), in particular PDE5, and have utility in a variety of therapeutic areas wherein such inhibition is considered beneficial, includin g the treatment of cardiovascular disorders and erectile dysfunction.