发明名称 |
MUTANT FORMS OF CHOLERA HOLOTOXIN AS AN ADJUVANT |
摘要 |
Mutant cholera holotoxins comprising a cholera toxin subunit (A) having sing le amino acid substitutions in the amino acid positions (16 or 72) or a double amino acid positions (16 and 68) or (68 and 72) have reduced toxicity compar ed to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self- molecule.
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申请公布号 |
CA2449663(A1) |
申请公布日期 |
2002.12.12 |
申请号 |
CA20022449663 |
申请日期 |
2002.06.05 |
申请人 |
UNIVERSITY OF COLORADO;WYETH HOLDINGS CORPORATION |
发明人 |
ZHU, DUZHANG;JOBLING, MICHAEL G.;GREEN, BRUCE A.;HOLMES, RANDALL K. |
分类号 |
C12N15/09;A61K39/00;A61K39/002;A61K39/008;A61K39/02;A61K39/095;A61K39/102;A61K39/12;A61K39/245;A61K39/35;A61K39/39;A61P35/00;C07K14/185;C07K14/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02;(IPC1-7):A61K39/42 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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