Production of injection molded shaped articles, especially for retarded drug release, by blending (meth)acrylate copolymer with plasticizer and other additives, degassing and molding

摘要

Production of injection molded shaped articles (I) comprises: (a) melting and blending a 1-4C alkyl (meth)acrylate/quaternary ammonio-alkyl (meth)acrylate copolymer (A) with plasticizer and adhesion inhibitor and/or parting agent and optionally pharmaceutical additives, auxiliaries and/or active agents; (b) degassing the mixture at 120 deg C or more; and (c) injecting the mixture into a mold at 80-160 deg C. Production of injection molded shaped articles (I) comprises: (a) melting and blending a radically polymerized copolymer (A) of 85-98 wt.% 1-4C alkyl (meth)acrylate and 15-2 wt.% quaternary ammonio-alkyl (meth)acrylate with 10-25 wt.% plasticizer and 10-50 wt.% adhesion inhibitor and/or 0.1-3 wt.% parting agent and optionally pharmaceutical additives, auxiliaries and/or active agents; (b) degassing the mixture at 120 deg C or more until the content of the lowest boiling component with a vapor pressure of 1.9 bar or more at 120 deg C is 0.5 wt. % or less, and (c) injecting the mixture into a mold at 80-160 deg C and demolding (I). An Independent claim is included for the articles (I) obtained by the process.