| 发明名称 |
MARKS AS MODIFIERS OF THE P53 PATHWAY AND METHODS OF USE |
| 摘要 |
Human MARK genes are identified as modulators of the p53 pathway, and thus a re therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.
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| 申请公布号 |
CA2448107(A1) |
申请公布日期 |
2002.12.12 |
| 申请号 |
CA20022448107 |
申请日期 |
2002.06.03 |
| 申请人 |
EXELIXIS INC. |
发明人 |
FUNKE, ROEL P.;BELVIN, MARCIA;LI, DANXI;FRANCIS-LANG, HELEN;PLOWMAN, GREGORY D.;LIOUBIN, MARIO N.;FRIEDMAN, LORI |
| 分类号 |
A61K31/7088;A61K39/395;A61K45/00;A61K48/00;A61P35/00;A61P43/00;C12N5/06;C12N5/10;C12N15/09;C12Q1/02;C12Q1/42;C12Q1/48;C12Q1/527;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;G01N33/573;G01N33/574;G01N33/68;(IPC1-7):C12Q1/68 |
主分类号 |
A61K31/7088 |
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