| 摘要 |
The invention relates to the use of derivatives of E-type prostaglandins as EP2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the invention are represented by the following formula I: wherein the hatched segment represents an alpha bonds, the solid triangle represents a beta bond, the wavy segments represent alpha or beta bond, dashed lines represent a double bond or a single bond R, , R1 , R2 and R3 are as defined in the specification.
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