摘要 |
The present invention is a method of targeting promoter-less selection cassettes into transcriptionally active loci. In particular, the invention is a method for targeting promoter-less selection cassettes into transcriptionally active loci in stem cells or other eukaryotic cells with much greater efficiency than previously observed with other methods, thus reducing or eliminating the need to screen for targeted cells. The invention also encompasses the DNA targeting vectors, the targeted cells, as well as non-human organisms, especially mice, created from the targeted cells.
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申请人 |
REGENERON PHARMACEUTICALS, INC.;ECONOMIDES, ARIS, N.;DECHIARA, THOMAS, M.;YANCOPOULOS, GEORGE, D. |
发明人 |
ECONOMIDES, ARIS, N.;DECHIARA, THOMAS, M.;YANCOPOULOS, GEORGE, D. |