发明名称 |
PRMTS AS MODIFIERS OF THE P53 PATHWAY AND METHODS OF USE |
摘要 |
Human PRMT genes are identified as modulators of the p53 pathway, and thus a re therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
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申请公布号 |
CA2449281(A1) |
申请公布日期 |
2002.12.12 |
申请号 |
CA20022449281 |
申请日期 |
2002.06.05 |
申请人 |
EXELIXIS INC. |
发明人 |
FUNKE, ROEL P.;FRANCIS-LANG, HELEN;LI, DANXI;FRIEDMAN, LORI;PLOWMAN, GREGORY D.;BELVIN, MARCIA |
分类号 |
A61K31/7088;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P9/00;A61P35/00;A61P43/00;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/02;C12Q1/02;C12Q1/25;C12Q1/42;C12Q1/48;C12Q1/527;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566;G01N33/567;G01N33/573;G01N33/574;G01N33/68;(IPC1-7):C12Q1/68;C12Q1/00;A61K31/708 |
主分类号 |
A61K31/7088 |
代理机构 |
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地址 |
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