Pharmaceutical composition containing antagonists of growth factor of vascular endothelial cells

摘要

(A) A compsn. is claimed comprising a human vascular endothelial growth factor (hVEGF) antagonist, provided however that the antagonist is not the flt or flk-1 or KOR receptor or a neutralising anti-hVEGF antibody. Also claimed are: (B) a monoclonal antibody (MAb) amino acid sequence capable of specifically binding to a HVEGF receptor (hVEGFr) or a hVEGF-hVEGFr; (C) a polypeptide comprising an amino acid sequence comprising a bVEGFr and an immunoglobulin chain; (D) a method of treatment of a tumour in a mammal comprising administering a HVEGF antagonist to reduce the size of the tumour.