METHOD FOR PREPARING LEVOSULPIRIDE AND INTERMEDIATES USED THEREIN

摘要

PURPOSE: Provided are a method for preparing Levosulpiride which increases the pressure of a sphincteral muscle, promotes the vermiculation of the gullet and facilitates digestion, in high yield and purity and intermediates used therein. CONSTITUTION: The method for preparing Levosulpiride of the formula(I) is characterized by treating a compound of the formula(V) with trifluoroacetate. In the formulae, R1 and R2 are independently hydrogen atom or 1-4 of lower alkyl or phenyl; R3 is a phenyl derivative of the formula(VIII) or naphthyl derivative of the formula(IX).