| 发明名称 |
Specific binding members for TGFbeta1 |
| 摘要 |
The invention provides specific binding members, for example in the form of antibody variable domains, based on the CDR3 sequences of the antibody VH regions of SL15 (SEQ ID NO:4) and JT182 (SEQ ID NO:10). The antibodies have strong neutralizing activity for TGFbeta1 and are useful in treating conditions associated with excess TGFbeta1 activity, such as fibrosis, immune responses and tumor progression.
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| 申请公布号 |
US6492497(B1) |
申请公布日期 |
2002.12.10 |
| 申请号 |
US20000560198 |
申请日期 |
2000.04.28 |
| 申请人 |
CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED |
发明人 |
THOMPSON JULIA ELIZABETH;LENNARD SIMON NICHOLAS;WILTON ALISON JANE;BRADDOCK PETA SALLY HELENA;DU FOU SARAH LEILA;MCCAFFERTY JOHN GERALD;CONROY LOUISE ANNE;TEMPEST PHILIP RONALD |
| 分类号 |
G01N33/53;A61K39/395;A61P11/06;A61P13/12;A61P17/02;A61P27/02;A61P27/06;A61P27/12;A61P29/00;A61P35/00;A61P35/02;A61P35/04;A61P37/00;A61P37/02;C07K16/22;C12N15/02;C12N15/13;C12P21/08;(IPC1-7):C07K16/22 |
主分类号 |
G01N33/53 |
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