发明名称 |
PTP-S31: a novel protein tyrosine phosphatase |
摘要 |
A novel protein tyrosine phosphatase designated PTP-S31 and its subfamily are identified, as are nucleic acid molecule coding therefor. Included in this;family are PTP-S31 proteins or glycoproteins having one, two, or three identified amino acid changes in previously defined consensus sequences in the catalytic phosphatase domains of known protein tyrosine phosphatases. The PTP-S31 proteins or glycoproteins may be produced by recombinant means. Antibodies to PTP-S31 proteins or glycoproteins and nucleic acid constructs coding therefor, and methods for screening molecules which can bind to PTP-S31 proteins or glycoproteins and inhibit or stimulate their enzymatic activity, are provided.
|
申请公布号 |
US6492495(B1) |
申请公布日期 |
2002.12.10 |
申请号 |
US19990361096 |
申请日期 |
1999.07.26 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
MOLLER NIELS PETER HUNDAHL;MOLLER KARIN BACH;ULLRICH AXEL |
分类号 |
G01N33/53;A61K38/00;A61K38/46;A61K39/395;A61P43/00;C07K14/47;C07K16/40;C12N1/21;C12N9/16;C12N9/18;C12N15/09;C12N15/55;C12P21/08;C12Q1/42;C12Q1/68;C12R1/19;G01N33/573;(IPC1-7):C07K16/00 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|