发明名称 |
UROKINASE INHIBITORS |
摘要 |
The invention relates to a highly active, highly specific urokinase inhibito r which is suitable for therapeutic applications and can be synthesized in an extremely simple manner. Surprisingly, it was found that amidino benzylamine derivatives, especially 4-amidino-benzylamine, with two bonded amino acids represent a new group of highly active and very selective uPA inhibitors The urokinase ihibitors can be used in medical applications, e;g. in the treatme nt of malign tumours such as in cases of metastatic spread.
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申请公布号 |
CA2411981(A1) |
申请公布日期 |
2002.12.09 |
申请号 |
CA20012411981 |
申请日期 |
2001.06.15 |
申请人 |
CURACYTE AG |
发明人 |
SCHWEINITZ, ANDREA;STEINMETZER, TORSTEN;KUNZEL, SEBASTIAN;STURZEBECHER, JORG |
分类号 |
C12N9/99;A61K9/02;A61K9/08;A61K9/16;A61K9/20;A61K9/28;A61K9/48;A61K9/70;A61K31/18;A61K38/00;A61P35/00;A61P43/00;C07K5/06;(IPC1-7):C07K5/062;A61K38/05;C07C281/06;G01N33/68 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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