METHOD FOR THE PREPARATION OF EPINASTINE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

摘要

PURPOSE: Provided is a method for the preparation of epinastine which treats and prevents ache dolor pain and migraine headache, and its pharmaceutically acceptable salt. CONSTITUTION: The method for the preparation of epinastine of the formula(I) is characterized by comprising the step of carrying out the reaction of 6-aminomethyl-6,11-dihydro-5H-dibenz(b,e) azepine of the formula(II) to cyanamid of the formula(III) or potassium cyanate rather than cyanogenbromide, bromine and N-methyl-benzylamine.