The present invention provides a method wherein yeast mutants deficient in the expression of the yeast homolog of frataxin are applied for the identification and/or evaluation of pharmaceutically active compounds. The invention concerns especially a method wherein the yeast strain W303-1B/ DELTA ydl120w::Kan<R> is applied for the identification and/or evaluation of chemical and biochemical compounds that protect W303-1B/ DELTA ydl120w::Kan<R> yeast from chemical stress. Furthermore, the invention concerns the application of said method in new cell-based assays to be used for drug screening.
申请公布号
WO0208445(A3)
申请公布日期
2002.12.05
申请号
WO2001EP07984
申请日期
2001.07.11
申请人
MYOCONTRACT PHARMACEUTICAL RESEARCH AG;MEIER, THOMAS;JAUSLIN, MATTHIAS;NUOFFER, CLAUDE, A.
发明人
MEIER, THOMAS;JAUSLIN, MATTHIAS;NUOFFER, CLAUDE, A.