NOVEL HETEROCYCLIC DERIVATIVES AND MEDICINAL USE THEREOF

摘要

Novel heterocyclic derivatives represented by the following general formula (I’) or pharmaceutically acceptable salts thereof: (I’) wherein R1 represents H or C1−6 alkyl; R2 represents −CO−C(R4)=C(R4)−R5 (wherein R4 represents H or C1−4 alkyl; and R5 represents C4−8 alkyl, C2−8 alkenyl, aryl or an aromatic heterocycle), −CO−CºR6 (wherein R6 represents C1−8 alkyl), etc.; R3 represents H or C1−4 alkyl; X represents O or S; R20 represents optionally substituted phenyl; and n is an integer of from 1 to 4. These compounds (I’) are useful as antihyperglycemics, antilipemics, insulin resistance−ameliorating drugs, remedies for diabetes, remedies for diabetic complications, drugs for ameliorating glucose tolerance insufficiency, antiarteriosclerotics, antiobestics, antiinflammatory agents, preventives/remedies for PPAR−mediate diseases and preventives/remedies for X syndrome.