CYTOTOXINS, PRODRUGS, LINKERS AND STABILIZERS USEFUL THEREFOR
摘要
The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleave d in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
申请公布号
CA2448319(A1)
申请公布日期
2002.12.05
申请号
CA20022448319
申请日期
2002.05.31
申请人
MEDAREX, INC.
发明人
KING, DAVID J.;LI, ZHIHONG;WU, GUOXIAN;GANGWAR, SANJEEV;MARTICHONOK, VALERI;LOBL, THOMAS J.;ASTAFIEVA, IRINA;MCGEE, DANNY P., C.;BOYD, SHARON;NG, HOWARD P.;MOORE, JIMMIE;SAUNDERS, OLIVER L.;YARRANTON, GEOFFREY THOMAS
