发明名称 NITRILE DERIVATIVES AS CATHEPSIN K INHIBITORS.
摘要 <p>The present invention relates to compounds of formula (I), wherein R1 to R7 and Y are as defined in the description and claims and pharmaceutically acceptable salts andor pharmaceutically acceptable esters thereof. The compounds are useful for the treatment of diseases which are associated with cystein proteases such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.</p>
申请公布号 MXPA02006163(A) 申请公布日期 2002.12.05
申请号 MX2002PA06163 申请日期 2000.12.13
申请人 F. HOFFMANN-LA ROCHE AG 发明人 GABRIEL, TOBIAS
分类号 A61K31/40;A61K31/401;A61K31/403;A61K31/426;A61P9/00;A61P9/10;A61P11/00;A61P13/12;A61P19/02;A61P19/10;A61P27/02;A61P29/00;A61P33/06;A61P35/04;A61P37/00;C07D207/16;C07D207/48;C07D209/52;C07D277/06;C07D403/06;C07D405/12;C07D405/14 主分类号 A61K31/40
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