2, 4-disubstituted pyrimidine-5-carboxamide derivatives as KCNQ potassium channel modulators

摘要

There is provided a method of treatment for disorders responsive to the modulation of KCNQ potassium channels by administering to a mammal in need thereof a therapeutically effective amount of a 2,4-disubstituted pyrimidine-5-carboxamide derivative of the Formula I wherein R1, R2, R3, R4 and R5 are as defined below. The present invention also provides pharmaceutical compositions comprising openers or activators of the KCNQ potassium channels and especially to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine.