发明名称 |
PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 |
摘要 |
The invention thus provides the compounds of formula (I) and pharmaceutically acceptable salts thereof, in which: R<1> and R<2> are independently selected from the group consisting of H, C1-6alkyl, C2-6alkenyl, C3-6alkynyl, C3-10cycloalkylC0-6alkyl and C4-12bridged cycloalkyl; R<3> is selected from the group consisting of C1-6alkyl, NH2 and R<5>CONH; R<4> is selected from the group consisting of CH2F, CHF2, CF3CH2, CF3CHF and CF3CF2; and R<5> is selected from the group consisting of H, C1-6alkyl, C1-6alkoxy, C1-6alkylOC1-6alkyl, phenyl, HO 2CC1-6alkyl, C1-6alkylOCOC1-6alkyl, C1-6alkylOCO, H2NC1-6alkyl, C1-6alkylOCONHC1-6alkyl and C1-6alkylCONHC1-6alkyl. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.
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申请公布号 |
WO02096427(A1) |
申请公布日期 |
2002.12.05 |
申请号 |
WO2002GB02414 |
申请日期 |
2002.05.23 |
申请人 |
GLAXO GROUP LIMITED;HARTLEY, CHARLES, DAVID;NAYLOR, ALAN;PAYNE, JEREMY, JOHN;PEGG, NEIL, ANTHONY |
发明人 |
GREEN, RICHARD, HOWARD DI;HARTLEY, CHARLES, DAVID;NAYLOR, ALAN;PAYNE, JEREMY, JOHN;PEGG, NEIL, ANTHONY |
分类号 |
A61K31/505;A61P1/00;A61P1/04;A61P1/16;A61P3/10;A61P9/00;A61P17/00;A61P17/02;A61P17/06;A61P19/00;A61P19/02;A61P19/06;A61P21/00;A61P25/00;A61P25/02;A61P25/04;A61P25/08;A61P29/00;A61P31/12;A61P31/16;A61P35/00;A61P43/00;C07D239/42;(IPC1-7):A61K31/505 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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地址 |
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