| 发明名称 |
SMALL MOLECULE ANTAGONISTS OF BCL2 FAMILY PROTEINS |
| 摘要 |
The present invention relates to naturally occurring and chemically synthesized small molecules antagonists of Bcl-2 family proteins. In particular, the present invention provides gossypol derivatives and methods of using gossypol derivatives as antagonists of the anti-apoptotic effects of B cl- 2 and Bcl-XL proteins especially in cancer cells that overexpress Bcl-2 fami ly proteins (e.g., Bcl-2 and/or Bcl-XL).
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| 申请公布号 |
CA2449245(A1) |
申请公布日期 |
2002.12.05 |
| 申请号 |
CA20022449245 |
申请日期 |
2002.05.30 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;GEORGETOWN UNIVERSITY MEDICAL CENTER |
发明人 |
WANG, SHAOMENG;YANG, DAJUN |
| 分类号 |
C12Q1/02;A61K31/11;A61K31/12;A61K31/122;A61K31/135;A61K31/19;A61K31/225;A61K31/335;A61K45/00;A61K45/06;A61P9/00;A61P31/04;A61P31/10;A61P31/12;A61P31/18;A61P35/00;A61P35/02;A61P43/00;(IPC1-7):A61K31/12 |
主分类号 |
C12Q1/02 |
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