发明名称 |
FUSION PROTEINS OF BIOLOGICALLY ACTIVE PEPTIDES AND ANTIBODIES |
摘要 |
A fusion protein is made up of (1) an antibody and (2) a peptide having a biological activity such as immuno-stimulatory, membrane transport and homophilic activities wherein the peptide is connected to the antibody at a site that does not interfere with antigen binding of the antibody. The fusion protein is made by the steps of creating a fusion gene including a nucleic acid sequence encoding an antibody and a nucleic acid sequence encoding the peptide, wherein the nucleic acid sequence encoding the peptide is located inside the nucleic acid sequence encoding the antibody at a site wherein, when the fusion is expressed, the fusion protein created thereby comprises the antibody and the peptide, wherein the peptide is connected to the antibody at a site that does not interfere with antigen binding of the antibody, and expressing the fusion gene to create the fusion protein. The peptide may be flanked by loop-forming or conformation-conferring sequences. |
申请公布号 |
WO02097041(A2) |
申请公布日期 |
2002.12.05 |
申请号 |
WO2002US16651 |
申请日期 |
2002.05.29 |
申请人 |
IMMPHERON, INC.;INNEXUS CORPORATION;KOHLER, HEINZ;MORGAN, CHARLES |
发明人 |
KOHLER, HEINZ;MORGAN, CHARLES |
分类号 |
A61K39/00;C07K14/47;C07K14/77;C07K16/00;C07K16/42 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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