ENHANCEMENT OF ORAL BIOAVAILABILITY OF NON-EMULSIFIED FORMULATION OF PRODRUG ESTERS WITH LECITHIN

摘要

A method for enhancing the oral bioavailability of a prodrug ester by formulating the ester as non-emulsified formulation with lecithin; as well a s a pharmaceutical composition of at least one antibiotic and lecithin in a no n- emulsified formulation; a method of treating infections with the non- emulsified formulation, and a method for preparing tablets by direct compression of blends of drugs with lecithin are disclosed. Non-emulsified formulations include solids, tablets, capsules, lozenges, suspensions, elixi rs and solutions, and exclude emulsions, liposomes, lipid matrix systems and micro-emulsions. A suitable prodrug ester is a cephalosporin .szlig.-lactam antibiotic such as cefditoren pivoxil, and a suitable non-emulsified formulation is a solid formulation.