发明名称 |
USES OF AGONISTS AND ANTAGONISTS TO MODULATE ACTIVITY OF TNF-RELATED MOLECULES |
摘要 |
<p>Methods of using one or more agonists or antagonists to modulate activity of the members of the TNF and TNFR families referred to as TALL-1, APRIL, TACI, and BCMA are provided. The methods include in vitro , in situ , and/or in vivo</i> diagnosis and/or treatment of mammalian cells or pathological conditions associated with TALL-1, APRIL, TACI, or BCMA, using one or more agonist or antagonist molecules. The methods of treatment disclosed by the invention include methods of treating immune related diseases and cancer.</p> |
申请公布号 |
WO0160397(A9) |
申请公布日期 |
2002.12.05 |
申请号 |
WO2000US32378 |
申请日期 |
2000.11.28 |
申请人 |
GENENTECH, INC. |
发明人 |
ASHKENAZI, AVI, J.;DODGE, KELLY, H.;GREWAL, IQBAL;KIM, KYUNG, JIN;MARSTERS, SCOT, A.;PITTI, ROBERT, M.;YAN, MINHONG |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K45/00;A61K47/48;A61P25/00;A61P29/00;A61P35/00;A61P35/02;A61P37/00;A61P37/06;A61P43/00;C07K14/52;C07K14/525;C07K14/705;C07K16/28;C07K16/46;C12N5/10;C12P21/08;(IPC1-7):A61K38/17;A61K38/18;A61K31/00;A61K38/19 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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