GENE DELIVERY SYSTEM AND METHODS OF USE

摘要

A recombinant replication competent retrovirus for gene delivery and gene therapy is provided. The recombinant retrovirus has a heterologous nucleic acid sequence, a sequence encoding a cell- or tissue-specific ligand or a sequence for transcriptional targeting, or a combination of both a cell- or tissue-specific ligand and a cell- or tissue-specific transcriptional targeting sequence.