发明名称 |
Antigen-specific IgM detection |
摘要 |
The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin M class in the presence of immunoglobulins of the G class and/or rheumatoid factors in body fluids by incubation with at least two different receptors R1 and R2 and optionally additional receptors wherein an essential component of R2 is a binding partner in a polymeric form and interference by IgG antibodies of the same antigen specificity is reduced by binding partners in a monomeric form; a reagent for determining an antigen-specific antibody of the immunoglobulin M class, as well as the use of binding partners in a monomeric form to reduce interference by IgG antibodies in the determination of antigen-specific IgM antibodies.
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申请公布号 |
US6489129(B1) |
申请公布日期 |
2002.12.03 |
申请号 |
US19990319084 |
申请日期 |
1999.11.15 |
申请人 |
ROCHE DIAGNOSTICS GMBH |
发明人 |
FAATZ ELKE;SCHMITT URBAN;OFENLOCH-HAHNLE BEATUS |
分类号 |
G01N33/53;G01N33/543;G01N33/569;G01N33/68;(IPC1-7):G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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