发明名称 |
Nucleic acid sequence and methods for selectively expressing a protein in a target cell or tissue |
摘要 |
A synthetic polynucleotide and a method are disclosed for selectively expressing a protein in a target cell or tissue of a mammal. Selective expression is effected by replacing at least one existing codon of a parent polynucleotide encoding a protein of interest with a synonymous codon to produce a synthetic polynucleotide having altered translational kinetics compared to the parent polynucleotide. The synonymous codon is selected such that it has a higher translational efficiency in the target cell or tissue relative to one or more other cells or tissues of the mammal.
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申请公布号 |
US6489141(B1) |
申请公布日期 |
2002.12.03 |
申请号 |
US20000479645 |
申请日期 |
2000.01.07 |
申请人 |
THE UNIVERSITY OF QUEENSLAND |
发明人 |
FRAZER IAN HECTOR;ZHOU JIAN |
分类号 |
C07K14/025;C07K14/435;C12N7/02;C12N15/67;C12N15/85;C12Q1/68;(IPC1-7):C12N15/64;C12N15/66;C12N15/63;C12N15/87 |
主分类号 |
C07K14/025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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