Tetrahydropyran derivatives and their use as therapeutic agents

摘要

The present invention relates to compounds of the formula (I):whereinR1 is fluorine or trifluoromethyl;R2 is fluorine or trifluoromethyl;R3 is methyl or hydroxymethyl;R4 represents a variety of substituents; andn is zero, 1 or 2;and pharmaceutically acceptable salts thereof.The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.