| 摘要 |
PURPOSE: Provided is a pharmaceutical composition for the prevention and treatment of tissue damage resulting from ischemia in mammals. CONSTITUTION: A pharmaceutical composition for the prevention and treatment of tissue damage resulting from ischemia in mammals comprises a compound of formula(1) or a prodrug of the compound, or a pharmaceutically acceptable salt of the compound or the prodrug. In the formula(1), R1 and R2 are each independently hydrogen or methyl; X and Y together are CH2-CH(OH)-Ar or CH2-C(O)-Ar, or X is a covalent bond, NR3 or CHR4, wherein, R3 is (C1-C3)alkyl or a phenyl that is optionally substituted with one or more substituents selected from OH, F, Cl, Br, I, CN, CF3, (C1-C6)alkyl, O-(C1-C6)alkyl, S(O)n-(C1-C6)alkyl and SO2-NR5R6, and R4 is hydrogen or methyl, and Y is a phenyl or naphthyl ring optionally substituted with one or more substituents selected from Ar, OH, F, Cl, Br, I, CN, CF3, (C1-C6)alkyl, O-(C1-C6)alkyl, S(O)n-(C1-C6)alkyl and SO2-NR5R6; Ar is a phenyl or naphthyl ring optionally substituted with one or more substituents selected from F, Cl, Br, I, CN, CF3, (C1-C6)alkyl, O-(C1-C6)alkyl, S(O)n-(C1-C6)alkyl and SO2-R5R6; n is independently for each occurrence 0, 1 or 2; R5 is independently for each occurrence H, (C1-C6)alkyl, phenyl or naphthyl; and R6 is independently for each occurrence (C1-C6)alkyl, phenyl or naphthyl.
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