发明名称 MEDICAMENTOS PARA TRATAR A RESTENOSE COMPREENDENDO POLIMEROS QUE LIBERTAM OXIDO NITRICO
摘要 Methods of amelioration, treatment and prevention for restenosis and related disorders are provided. Methods involve the administration of nitric oxide by a nitric oxide delivery means comprising a restenosis-ameliorating or therapeutically/prophylactically effective amount of either a polymer to which is bound a nitric oxide-releasing N2O2- functional group a compound comprising a nitric oxide-releasing N2O2- functional group. Also provided are nitric oxide delivery means comprising such nitric oxide-releasing polymers or compounds for use in such methods. Preferably, the delivery means is coated with a nitric oxide-releasing polymer, which may be biodegradable, and enables the controllable and predictable release of NO to a given site in such a manner that effective ameliorating, prophylactic or therapeutic dosing is realized.
申请公布号 PT752866(E) 申请公布日期 2002.11.29
申请号 PT19950912871T 申请日期 1995.03.09
申请人 COMEDICUS, INC.;GOV. U.S.A.,THE,REPR.BY SER.DEP.HEALTH HUMAN SERV. 发明人 LARRY K. KEEFER;THOMAS C. HUTSELL
分类号 C07D295/12;A61K9/00;A61K31/44;A61K31/445;A61K31/495;A61K31/655;A61K31/785;A61K38/00;A61K47/48;A61P9/08;C07D295/22;C08F8/30 主分类号 C07D295/12
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