| 摘要 |
<p>The present invention provides compositions which allow for the extended release and enhanced bioavailability of biologically active polypeptides following parenteral delivery to an animal. More particularly, it concerns compositions comprising biologically active somatotropin formulated for extended release, methods of preparing these compositions, and methods of using the same. These compositions comprise somatotropin, a bioavailability enhancing constituent (BEC), and a substantially non aqueous, hydrophobic excipient. The BEC may comprise (i) amino acids or amino acid derivatives, such as histidine HC1; (ii) hydroxamate derivatives, such as histidine hydroxamate or suberohydroxamic acid; (iii) non reducing carbohydrates, such as trehalose or trehalose octaacetate; (iv) oxo acid salts, such as a mixture of monobasic and dibasic sodium phosphate; or (v) a mixture of two or more compounds from within the foregoing classes (i) (iv).</p> |
