| 摘要 |
<p>The invention relates to chemical processes and chemical intermediates which are useful in the selective formation of a primary mono phosphoryl group ( OPO(OH2)) in a terminal 1, 2 diol propanoyl (HO CH2CH(OH) CO ) containing system, and to chemical processes and chemical intermediates (and processes for their manufacture) particularly useful for the manufacture of anti Gram positive oxazolidinone bacterial agents containing such functionality, in particular for the preparation of 5(R) Isoxazol 3 yloxymethyl 3 (4 (1 (2(S) hychoxy 3 phosphoryl propanoyl) 1,2,5, 6 tetrahydropyridy 4 il)3,5 difluorophenyl)oxazolidin 2 one.</p> |
