发明名称 |
USE OF ESTROGEN RECEPTOR MODULATORS IN COMBINATION WITH SEXUAL STEROID PRECURSORS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS |
摘要 |
Novel methods for the medical treatment and/or inhibition of the development of breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warmblooded animals including humans involving administration of selective estrogen receptor modulator and an amount of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-ene-3²,17²-diol, and compounds converted in vivo to one of the foregoing precursors. Further administration of bisphosphonates in combination with selective estrogen receptor modulators and/or sex steroid precursors is disclosed. Pharmaceutical compositions for delivery of active ingredients and kits useful to the invention are disclosed. |
申请公布号 |
HU0103345(A3) |
申请公布日期 |
2002.11.28 |
申请号 |
HU20010003345 |
申请日期 |
1999.06.10 |
申请人 |
ENDORECHERCHE, INC., SAINTE-FOY, QUEBEC |
发明人 |
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分类号 |
C07D333/56;A61K31/133;A61K31/381;A61K31/40;A61K31/4025;A61K31/403;A61K31/404;A61K31/4436;A61K31/4453;A61K31/453;A61K31/475;A61K31/56;A61K31/565;A61K31/568;A61K31/5685;A61K31/57;A61K31/66;A61K45/00;A61K45/06;A61P3/06;A61P9/10;A61P15/00;A61P15/02;A61P19/10;A61P21/00;A61P35/00;C07D209/10;C07D311/60 |
主分类号 |
C07D333/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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