A process for the preparation of diols by a Lewis acid-catalysed aldehyde addition reaction on hydroxyalkynes followed by hydrogenation is described. The process provides a wide range of diols from simple, readily available starting materials. In particular the process is suitable for preparing chiral 1,4-diols suitable for the preparation of chiral phospholane ligands for use in asymmetric catalysis.
申请公布号
WO02094741(A1)
申请公布日期
2002.11.28
申请号
WO2002GB01958
申请日期
2002.04.29
申请人
IMPERIAL CHEMICAL INDUSTRIES PLC;ADGER, BRIAN, MICHAEL;CARREIRA, ERICK, MORAN