发明名称 |
COMPOUNDS THAT INHIBIT HSP90 AND STIMULATE HSP70 AND HSP40, USEFUL IN THE PREVENTION OR TREATMENT OF DISEASES ASSOCIATED WITH PROTEIN AGGREGATION AND AMYLOID FORMATION |
摘要 |
The present invention relates t o the use of a compound or a plurality of compounds that inhibit function of Hsp90; or activate expression of both Hsp40 and Hsp70 for the preparation of a pharmaceutical composition for the prevention or treatment of a disease associated with protein aggregation and amyloid formation. Preferably, said compound is geldanamycin. The present invention relates further to methods of producing compounds within proved potency and/or decreased side-effects that may be successfully employed as medicaments for the treatment of said diseases. |
申请公布号 |
WO02094259(A1) |
申请公布日期 |
2002.11.28 |
申请号 |
WO2002EP04893 |
申请日期 |
2002.05.03 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.;WANKER, ERICH;SITTLER, ANNIE;HARTL, ULRICH |
发明人 |
WANKER, ERICH;SITTLER, ANNIE;HARTL, ULRICH |
分类号 |
A61K31/00;A61K31/365;A61K31/395;A61P25/28;G01N33/566;G01N33/68 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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