发明名称 |
METHODS FOR ATTENUATION OF VIRULENCE IN BACTERIA |
摘要 |
The present invention provides methods of putatively identifYing, based on presence of rare codon usage, cellular components involved in virulence. Also included are methods of verifying putati ve virulence genes and methods of attenuating such virulence, e.g., through identification and modification of genes/gene products that modulate translation of gene subsets involved in pathogen virulence. The methods include examining the codon usage and frequency employed in the organism, and identifying and structurally characterizing, e.g., tRNA molecules associated with over- represented or under-represented codons. By targeting the cell's ability to decode specific sets of genes, the virulence of a pathogen can be modulated. |
申请公布号 |
WO02095363(A2) |
申请公布日期 |
2002.11.28 |
申请号 |
WO2002US16785 |
申请日期 |
2002.05.28 |
申请人 |
TAO BIOSCIENCES, LLC;MITCHELL, WAYNE;COTA, ADAM;ROBERTS, T., GUY |
发明人 |
MITCHELL, WAYNE;COTA, ADAM;ROBERTS, T., GUY |
分类号 |
C12N15/10;C12N15/67;C12Q1/68;G01N33/48;G01N33/50;G06F19/18 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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