发明名称 |
AZA HYDROXYLATED ETHYL AMINE COMPOUNDS |
摘要 |
Disclosed are compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein RN, RC, R1, R2 and R20 are defined herei n. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
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申请公布号 |
CA2448084(A1) |
申请公布日期 |
2002.11.28 |
申请号 |
CA20022448084 |
申请日期 |
2002.05.22 |
申请人 |
ELAN PHARMACEUTICALS, INC.;PHARMACIA & UPJOHN COMPANY |
发明人 |
SCHOSTAREZ, HEINRICH;CHRUSCIEL, ROBERT ALLAN;CENTKO, REBECCA S. |
分类号 |
C07D277/20;A61K31/166;A61K31/18;A61K31/426;A61P25/00;A61P25/16;A61P25/28;A61P43/00;C07C243/28;C07C243/32;C07C311/16;C07C311/49;C07D277/56;(IPC1-7):C07C243/28;A61K31/16 |
主分类号 |
C07D277/20 |
代理机构 |
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