摘要 |
Pharmaceutical composition comprising, as a first anti-neoplastic drug, cyanoguanidine IKK inhibitors, and in particular compounds of formula (I) wherein n is 0, 1 or 2; each R independently represents halogen, trifluoromethyl, hydroxy, C1-4alkyl, C1-4alkoxy, C1-4alkoxycarbonyl, nitro, sulfo, cyano, amino or carboxy groups; Q is a straight or branched, saturate d or unsaturated C4-20 divalent hydrocarbon radical; X is a bond, amino, O, S, carbonyl, carbonylamino, aminocarbonyl, oxycarbonyloxy, oxycarbonyl, carbonyloxy, aminocarbonyloxy, aminothiocarbonyloxy, oxycarbonylamino or oxythiocarbonylamino; A is di-(C1-4alkoxy)phospinoyloxy, C1-4alkoxycarbonyl, C1-4alkoxycarbonylamino, C3-12 carbocyclic ring or C3-12 heterocarbocyclic ring optionally subtituted with one or more R1; R1 being independently selected from the group consisting of halogen, trifluoromethyl, hydroxy, C1- 4alkyl, C1-4alkoxy, C1-4alkoxycarbonyl, nitro, cyano, amino, sulfo, carboxy, carboxamido, sulfamoyl or C1-4hydroxyalkyl; in combination with a second ant i- neoplastic drug are provided.
|