发明名称 |
METHOD FOR IN SITU, ON-CHIP CHEMICAL SYNTHESIS |
摘要 |
Apparatus and methods for the synthesis of arrays of molecules bound to a substrate, and in particular oligomeric molecules such as DNA oligonucleotides and peptides. The methods of the invention comprise providing a substrate having first and second surfaces and a plurality of isolated porous regions extending through the substrate and communicating with the first and second surfaces, contacting selected ones of the porous regions with a reagent, allowing the reagent to bind to or otherwise interact with the selected porous regions, and withdrawing unreacted first reagent from the substrate through the selected porous regions by introducing a pressure differential across the substrate. The events may be repeated as required to form oligomeric molecules. |
申请公布号 |
WO02094846(A2) |
申请公布日期 |
2002.11.28 |
申请号 |
WO2002US16403 |
申请日期 |
2002.05.22 |
申请人 |
PARALLEL SYNTHESIS TECHNOLOGIES, INC.;HAUSHALTER, ROBERT, C. |
发明人 |
HAUSHALTER, ROBERT, C. |
分类号 |
C07B61/00 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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