CHLOROMETHYLATION OF THIOPHENE

摘要

The process according to the invention relates to the preparation of 2- chloromethyl-thiophene of the formula (I). During this process thiophene is chloromethylated in the presence of one or more compounds containing keto group and optionally it is transformed into the compound of the formula (II) . Compounds of formula (I) and (II) are intermediates of several pharmaceutically active ingredients.