The present invention provides methods for identifying peptides in a mammalian Tsg101 protein that binds to the PTAPP motif or L domain of human immunodeficiency virus type I (HIV-1). Such peptides can be used to inhibit Tsg101-HIV Gag binding, and is therefore effective in reducing HIV particle production. The invention also provides the peptides identified by the method of the invention and to method of using such peptides for treating HIV infection.
申请公布号
WO02094314(A1)
申请公布日期
2002.11.28
申请号
WO2002US15965
申请日期
2002.05.21
申请人
THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OFNEW YORK;COHEN, STANLEY, N.;CARTER, CAROL;GOFF, ARTHUR;EHRLICH, LORNA