IMMUNE MODULATION BY TRANSDUCED HEMATOPOIETIC STEM CELLS EXPRESSING ANTIGENS AND ANTIGEN-PRESENTING CELL REGULATORY MOLECULES
摘要
The invention provides methods and compositions for the modulation of systemic immune responses by transplantation of hematopoietic stem cells transduced with genes encoding antigens and antigen presenting cell regulatory molecules. The invention includes bi-cistronic lentiviral expression vectors adapted for antigen expression in antigen presenting cells for use in DNA vaccines directed against pathogens and tumor antigens as well as for the treatment of autoimmune disease and for the establishment of antigen tolerance.
申请公布号
WO02074345(A3)
申请公布日期
2002.11.28
申请号
WO2002US08411
申请日期
2002.03.18
申请人
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;PARDOLL, DREW, M.;CHENG, LINZHAO;CUI, YAN;CIVIN, CURT, I.;WHARTENBY, KATHERINE